A Review of Therapeutic Applications of Nutraceuticals in Polycystic Ovarian Disease

Review Article

Abstract

Polycystic Ovarian Disease (PCOD) represents a complex endocrine disorder affecting reproductive-age women worldwide. The condition manifests through various symptoms including irregular menstruation, hormonal imbalances, insulin resistance, and metabolic disruptions. While conventional pharmaceutical interventions remain the primary treatment approach, nutraceuticals have emerged as promising complementary therapeutic agents. This analysis explores the scientific basis and clinical applications of various nutraceuticals in PCOD management. Natural compounds such as Ashwagandha (Withania somnifera), Cinnamon (Cinnamomum verum), Fenugreek (Trigonella foenum-graecum), and Holy Basil (Ocimum sanctum) demonstrate significant potential in addressing multiple pathophysiological aspects of PCOD. These compounds work through various mechanisms including hormone regulation, insulin sensitization, anti-inflammatory effects, and oxidative stress reduction. Clinical evidence suggests that these nutraceuticals, when used as adjunct therapy, may improve menstrual regularity, reduce androgen levels, enhance insulin sensitivity, and alleviate metabolic disturbances. Additionally, nutraceuticals like Chaste berry, Licorice, and Aloe vera show promise in managing specific PCOD symptoms