Quinoline Based 2-Azetidinones, 4-Thiazolidinones and Their Potential Pharmacological Activities

Review Article

Abstract

Globally, many diseases with unmet therapeutic needs persist, including cancer, tuberculosis, and various infectious diseases. The rapid development of new drugs is crucial to counteract these health challenges. Medicinal chemists, in collaboration with other scientists, continuously strive to design and develop novel lead molecules with potential therapeutic applications. Molecular hybridization is a common approach in this field, often resulting in the synthesis of new compounds with synergistic or novel activities. Quinoline-based hybrid molecules, particularly those incorporating 2-azetidinone and 4-thiazolidinone moieties, have shown promise in addressing multiple disease targets. These hybrid derivatives have demonstrated potential efficacy against infectious diseases, cancer, and tuberculosis. The combination of quinoline, a privileged scaffold in medicinal chemistry, with 2-azetidinones and 4-thiazolidinones, known for their diverse therapeutic properties, offers a promising avenue for drug discovery. Ongoing research in this area aims to uncover new lead molecules that could significantly impact the treatment of diseases with current therapeutic limitations