Recent Advances in Drug Delivery Systems for Targeting the Blood-Brain Barrier

Review Article

Abstract

The blood-brain barrier (BBB) poses a significant challenge in treating central nervous system (CNS) disorders, limiting the efficacy of many potential therapeutic agents. Overcoming this barrier is crucial for enhancing drug delivery to the brain. Recent advancements in drug delivery systems have shown promising results in addressing this challenge. Both invasive and non-invasive strategies, including chemical modifications, colloidal systems, and biological techniques, have been developed to improve brain drug targeting. Nanoparticle-based delivery systems, such as liposomes, polymeric micelles, and dendrimers, demonstrate enhanced drug penetration and targeting capabilities. Advanced techniques like focused ultrasound-mediated BBB disruption and convection-enhanced delivery offer novel approaches to circumvent the BBB. Additionally, intranasal delivery and cell-penetrating peptides present alternative routes for CNS drug administration. These innovative approaches span a wide range of applications, from neurodegenerative diseases to brain tumors, potentially revolutionizing treatment strategies for various CNS disorders. The ongoing research and emerging trends in brain-targeted drug delivery systems provide a foundation for developing more effective therapies, offering hope for improved outcomes in patients with CNS diseases