Current Advances in Nanotechnology-Based Drug Delivery Systems

Review Article

Abstract

Nanotechnology is a revolutionary trend in pharmaceutical sciences, particularly in drug delivery systems. The usage of nanoscale materials and devices in medicine has revolutionized therapeutic strategies across various diseases, from cancer to cardiovascular disorders. Nanocarrier systems, ranging from 1-100 nanometers, demonstrate remarkable capabilities in enhancing drug solubility, bioavailability, and targeted delivery. These systems include micelles, liposomes, dendrimers, carbon nanotubes, metallic nanoparticles, and quantum dots, each offering unique advantages in drug encapsulation and delivery. The application of both passive and active targeting mechanisms has enabled precise drug delivery to specific tissues while minimizing systemic exposure. Novel delivery approaches such as self-nano-emulsions provide protective measures for drugs, enhance their properties, and facilitate controlled release at targeted sites. The therapeutic applications span across multiple medical conditions, including gastrointestinal disorders, bone regeneration, retinal diseases, diabetes, tuberculosis, and cancer. Despite remarkable progress, challenges remain in scaling up production, ensuring safety, and navigating regulatory requirements. The convergence of nanotechnology with other cutting-edge fields presents opportunities for developing more sophisticated drug delivery platforms. The successful implementation of these nanosystems has demonstrated reduced side effects, improved therapeutic efficacy, and enhanced patient outcomes, marking a significant advancement in pharmaceutical technology and patient care.