Comprehensive Review on Tablet Coating Problems and Remedies

Review Article

Abstract

Pharmaceutical coating plays a crucial role in enhancing the organoleptic properties of solid pharmaceutical dosage forms. The tablet coating process is particularly pivotal for manufacturing tablets with controlled or delayed release profiles, improving the stability of dosage forms. This coating can be applied to various oral solid dosage forms like particles, powders, granules, crystals, pellets, and tablets. However, troubleshooting problems such as twinning, mottling, and chipping may occur due to faults in tablet core, coating formulation, or coating process. Overcoming these issues is essential to prevent unnecessary product complications. When a coating composition is applied, a tacky polymeric film covers the tablet surfaces. Various techniques, including sugar coating, film coating, and enteric coating, have been employed, with recent advancements minimizing the drawbacks associated with older methods. Modern coating technologies directly apply coating materials to the tablet surface without using solvents, aligning with ICH guidelines that emphasize solvent-free formulations for pharmaceutical safety. This review discusses the fundamental aspects of tablet coating, outlines common process challenges, and explores potential remedies