Design and Development, In vitro Characterization of Gastro Retentive Floating Tablets of Anti-Ulcer Drug

Research Article

Authors

  • Dr Vijaykumar Darshanam HOD & Professor, Department of Pharmaceutics, Swami Vivekananda Institute of Pharmaceutical Sciences, Vangapally, Yadagirigutta, Telangana, India Author
  • Dr. Madhusudhan Merugu HOD & Professor, Department of Pharmaceutics, Swami Vivekananda Institute of Pharmaceutical Sciences, Vangapally, Yadagirigutta, Telangana, India Author

Keywords:

Famotidine, Floating System, Antiulcer Activity, HPMC K4M, HPMC K15M

Abstract

The objective of this study was to design a delayed release formulation of Famotidine, aimed at sustaining therapeutic drug concentrations for an extended period exceeding 12 hours. Famotidine was administered at a fixed dose of 40 mg, and the total tablet weight was set at 250 mg. Hydroxypropyl methylcellulose (HPMC) derivatives, specifically HPMC K4M and HPMC K15M, were employed as polymer matrices at concentrations of 20, 40, and 80 mg. All formulations successfully met established physicochemical criteria, falling within predetermined limits. Dissolution studies revealed that formulation F6 exhibited superior and desired drug release characteristics, achieving a release rate of 96.33% within the 12-hour timeframe. Furthermore, the release mechanism of this formulation was found to conform to the Higuchi release kinetics model

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Published

25-10-2023

Issue

Vol. 1 No. 1 (2023): October 2023

Section

Articles

License

Copyright (c) 2023 Journal of Pharma Insights and Research

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

Design and Development, In vitro Characterization of Gastro Retentive Floating Tablets of Anti-Ulcer Drug: Research Article. (2023). Journal of Pharma Insights and Research, 1(1), 7-10. https://jopir.in/index.php/journals/article/view/6