Herbal efficacy of polyphenols used in the therapy of Alzheimer’s disease

Short Communication

Abstract

As a common cause of dementia, Alzheimer's disease has gained international attention due to its progressive nature. The primary causes of Alzheimer's disease are oxidative damage and aggregated protein buildup (tau and beta-amyloid proteins). Alzheimer's patients can lose their ability to remember things, learn new skills, or speak languages. As the condition progresses, they may also become depressed and aggressive. Current studies have focused on polyphenols, which are secondary metabolites found in plants and include flavonoids, tannic acid, resveratrol, curcumin, quercetin, rutin, genistein, daidzein, ellagitannins, and proanthocyanins. They could be able to lessen the rate at which Alzheimer's develops. Plant-based products contain polyphenols, which are the phenol groups generated from phytochemicals. Anti-oxidant, anti-inflammatory, anti-amyloidogenic, anti-viral/bacteria, and anti-carcinogenic qualities are displayed by polyphenols. Thus, every polyphenol has a role in the management of Alzheimer's. Through the modulation of signalling pathways, the polyphenols' mode of action in Alzheimer's disease includes the suppression of aggregated beta-amyloid plaque proteins, tau protein aggregation, oxidative stress, and inflammation. Consuming meals high in polyphenols may benefit the signalling pathways in neurons. Due to a significant biotransformation mediated by phase 1 and phase 2 reactions in the liver and gut bacteria, polyphenols have low bioavailability. By reducing the disease's toxicity, polyphenols aim to primarily slow the disease's progression and symptoms. In conclusion, In summary, the diverse array of polyphenols found in plant-based products holds promise in managing Alzheimer's disease by targeting oxidative stress, inflammation, and protein aggregation, offering a potential avenue to slow disease progression and alleviate symptoms