Literature Review on Analytical Method Development and Validation of Alfuzosin Hydrochloride

Review Article

Authors

  • Gagana Aradhya Assistant Professor, Department of Pharmaceutical Chemistry, Bharathi College of Pharmacy, Bharathinagara, Mandya district, Karnataka, India Author
  • Srujan Gowda S UG Scholar, Department of Pharmaceutical Chemistry, Bharathi College of Pharmacy, Bharathinagara, Mandya district, Karnataka, India Author
  • Preethi A P UG Scholar, Department of Pharmaceutical Chemistry, Bharathi College of Pharmacy, Bharathinagara, Mandya district, Karnataka, India Author
  • Mohan B UG Scholar, Department of Pharmaceutical Chemistry, Bharathi College of Pharmacy, Bharathinagara, Mandya district, Karnataka, India Author
  • Harshad V UG Scholar, Department of Pharmaceutical Chemistry, Bharathi College of Pharmacy, Bharathinagara, Mandya district, Karnataka, India Author

DOI:

https://doi.org/10.69613/06st8337

Keywords:

Alfuzosin hydrochloride, Method development, Method validation, RP-HPLC, HPTLC, UPLC

Abstract

Alfuzosin hydrochloride, an alpha-adrenergic blocker, is extensively used in the treatment of benign prostatic hyperplasia. Robust and reliable analytical methods are indispensable for quantifying alfuzosin hydrochloride in various matrices, ensuring the quality, efficacy, and safety of the drug. Recent advancements in analytical method development and validation for alfuzosin hydrochloride encompass a spectrum of techniques, including UV spectrometry, RP-HPLC, HPTLC, UPLC, and voltammetry. Optimization of chromatographic conditions, such as mobile phase composition, column selection, and detection wavelength, is crucial for achieving optimal separation and quantification of the drug. Method validation parameters, including accuracy, precision, linearity, and robustness, are assessed in accordance with ICH guidelines. These analytical methods find application in the determination of alfuzosin hydrochloride in bulk drugs, pharmaceutical formulations, and biological matrices. Stability-indicating methods are developed to evaluate drug stability under various stress conditions. The current state of analytical method development and validation for alfuzosin hydrochloride facilitates the selection of suitable analytical techniques for routine quality control and research purposes

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Published

04-08-2024

Issue

Section

Articles

How to Cite

Literature Review on Analytical Method Development and Validation of Alfuzosin Hydrochloride: Review Article. (2024). Journal of Pharma Insights and Research, 2(4), 234-240. https://doi.org/10.69613/06st8337