A Comprehensive Review on Therapeutic potentials of Matricaria chamomilla (chamomile) Against Inflammation-Mediated Chronic Diseases

Review Article

Abstract

Matricaria chamomilla, commonly known as chamomile, is a widely used medicinal plant renowned for its anti-inflammatory properties. Chronic inflammation plays a pivotal role in the pathogenesis of many disorders including metabolic syndrome, arthritis, inflammatory bowel disease and cancer. This comprehensive review explores the phytochemistry, traditional uses, pharmacological activities and molecular mechanisms of chamomile against inflammation-driven chronic illnesses. Chamomile contains several bioactive constituents such as flavonoids, terpenoids and phenolic compounds that exert anti-inflammatory effects by inhibiting pro-inflammatory cytokines, targeting redox imbalance and modulating critical inflammatory signaling cascades like NF-kB and MAPK pathways. Accumulating experimental and clinical evidence indicate that chamomile extracts and isolated compounds effectively reduce inflammation and ameliorate disease symptoms in various chronic conditions. However, more rigorous human trials are still warranted to validate its therapeutic efficacy and fully harness chamomile's anti-inflammatory potential. This review provides insights into chamomile's anti-inflammatory properties and its role as an adjuvant or alternative therapy for chronic inflammatory disorders