Liposome Based Nanoparticles for Gene Therapy: A Review

Review Article

Abstract

There has been a growing significance of nanomaterials, particularly lipid-based nanoparticles (LNPs), as a promising alternative to conventional medication delivery methods. Over the past decade, LNPs have gained substantial attention in both preclinical and clinical research due to their remarkable pharmacological performance and potential therapeutic effects. This article specifically focuses on the application of nanoparticle-based liposome drug delivery systems (DDS) in the field of gene therapy. The study of these liposomal carriers for gene therapy is motivated by their ability to enhance the targeted delivery of therapeutic genes. The review discusses the rationale behind utilizing such a drug delivery system, emphasizing its potential to address existing challenges in gene therapy. Various aspects related to nanoparticle-based liposome DDS, such as formulation strategies, targeting mechanisms, and therapeutic efficacy, are thoroughly examined. Additionally, the article focusses on the current state of research and development in this domain, shedding light on recent advancements and emerging trends. The overall goal is to showcase the significant promise and potential of integrating nanotechnology with liposomal carriers for gene therapy applications